Run exe in proton prefix

cd /path/to/steam/steamapps/compatdata/20920/pfx

STEAM_COMPAT_DATA_PATH="/path/to/steam/steamapps/compatdata/20920" WINEPREFIX=$PWD \
    "$HOME/.steam/root/steamapps/common/Proton 5.0/proton" run ./drive_c/path/to/custom_application.exe

Source: gist.github.com

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